Oxford Nanopore sequencers perform single-molecule long read sequencing of DNA and RNA
Oxford Nanopore have developed a proprietary method for sequencing DNA and RNA through a membrane, detecting base sequence through voltage changes.
Nanopore sequencing uses a helicase to unwind double stranded DNA at a certain speed. Unwound single strands are translocated through biological nanopores as current shifts, corresponding to specific nucleic acid motifs, are recorded in real-time. In addition to DNA Sequencing, nanopore sequencing can also be used for inferring base modifications, such as DNA- and RNA methylation.
To learn more about technology, visit Oxford Nanopore Technologies official site.