Production of high-quality proximity ligation libraries, using two restriction enzymes.
chromatin scaffolding library preparation epigenetics TADs illumina de novoA proximity-ligation protocol using a sequence-independent endonuclease, generating data for TAD identification and scaffolding.
chromatin scaffolding library preparation epigenetics TADs illumina de novoNGI can generate high quality assemblies using IPA and hifiasm assemblers
scaffolding assembly pacbio hifi hifiasm ipa hic omnic