Methods to scaffold contigs together and correct genome assembly errors.
Production of high-quality proximity ligation libraries, using two restriction enzymes.TADs illumina de novo chromatin scaffolding library preparation epigenetics
A proximity-ligation protocol using a sequence-independent endonuclease, generating data for TAD identification and scaffolding.TADs illumina de novo chromatin scaffolding library preparation epigenetics
Nanopore instruments can sequence very long continuous fragments of DNA. Sequencing native DNA allows detection of base modifications.long-read nanopore assembly
PacBio SMRT sequencing generates reads tens of kilobases in length enabling high quality genome assembly, structural variant analysis, amplicon resequencing, full-length transcript isoform sequencing, full-length 16S rRNA sequencing and amplification free epigenetic characterization.smrt assembly pacbio methylation amplicon sequel hifi clr de novo iso seq sv